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Sex Chromosome Abnormalities The majority of known types of chromosomal abnormalities involve sex chromosomes. In frequency of occurrence, they are only slightly less common than autosomal abnormalities. However, they are usually much less severe in their effects. The high frequency of people with sex chromosome aberrations is partly due to the fact that they are rarely lethal conditions. Like Down syndrome and other autosomal problems, sex chromosome gross abnormalities can be diagnosed before birth by amniocentesis and chorionic villi sampling.Sex chromosome abnormalities occur as a result of chromosome mutations Over time, some of the mutations on the Y chromosome have resulted If a cell has an additional chromosome, (three instead of two), it is trisomic. Klinefelter syndrome is a chromosomal condition in boys and men that can affect Boys and men with Klinefelter syndrome typically have small testes that Testosterone is the hormone that directs male sexual development before birth and . Chromosomal variants in klinefelter syndrome. Sex Dev. ;5(3) doi. Available data suggest a 3–4-fold increase of sex chromosomal abnormalities, i.e. % in ICSI children compared with % of all births (Bonduelle et al...the end of the story look at the video above ↑ ↑ ↑

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